解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::We have obtained the 1.7 A crystal structure of FIV protease (PR) in which 12 critical residues around the active site have been substituted with the structurally equivalent residues of HIV PR (12X FIV PR). The chimeric PR was crystallized in complex with the broad-based inhibitor TL-3, which inhibits wild type FIV an...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/1742-4690-4-1
更新日期:2007-01-09 00:00:00
abstract::Sidaction's appeal regarding the sentencing of medical personnels in the Libyan-HIV infection cases. ...
journal_title:Retrovirology
pub_type: 社论
doi:10.1186/1742-4690-3-98
更新日期:2006-12-27 00:00:00
abstract:BACKGROUND:Emergence of drug-resistant strains of human immunodeficiency virus type 1 (HIV-1) is a major obstacle to successful antiretroviral therapy (ART) in HIV-infected patients. Whether antiviral immunity can augment ART by suppressing replication of drug-resistant HIV-1 in humans is not well understood, but can b...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/1742-4690-3-97
更新日期:2006-12-21 00:00:00
abstract:BACKGROUND:While viruses have long been shown to capitalize on their limited genomic size by utilizing both strands of DNA or complementary DNA/RNA intermediates to code for viral proteins, it has been assumed that human retroviruses have all their major proteins translated only from the plus or sense strand of RNA, de...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/1742-4690-3-80
更新日期:2006-11-08 00:00:00
abstract:BACKGROUND:We have previously reported that CD4 T cells from some exposed uninfected (EU) Vietnamese intravenous drug users are relatively resistant to HIV infection in vitro. Here, we further characterized the restriction of viral replication in CD4 T cells from five EUs and assessed its persistence in serial samples....
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/1742-4690-3-81
更新日期:2006-11-08 00:00:00
abstract::In order to characterize the antiviral activity of human TRIM5alpha in more detail human derived indicator cell lines over expressing wild type human TRIM5alpha were generated and challenged with HIV-1 and HIV-2 viruses pseudotyped with HIV envelope proteins in comparison to VSV-G pseudotyped particles. HIV envelope p...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/1742-4690-3-79
更新日期:2006-11-06 00:00:00
abstract::In the mid-1990's, researchers hypothesized, based on new viral load data, that HIV-1 causes CD4+ T-cell depletion by direct cytopathic effect. New data from non-human primate studies has raised doubts about this model of HIV-1 pathogenesis. Despite having high levels of viremia, most SIV infections are well tolerated...
journal_title:Retrovirology
pub_type: 社论
doi:10.1186/1742-4690-3-60
更新日期:2006-09-08 00:00:00
abstract:BACKGROUND:Certain murine leukemia viruses (MLVs) are capable of inducing progressive spongiform motor neuron disease in susceptible mice upon infection of the central nervous system (CNS). The major CNS parenchymal target of these neurovirulent retroviruses (NVs) are the microglia, whose infection is largely coinciden...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/1742-4690-3-26
更新日期:2006-05-12 00:00:00
abstract:BACKGROUND:The Tax proteins encoded by human T lymphotropic virus type 1 (HTLV-1) and type 2 (HTLV-2) are transcriptional activators of both the viral long terminal repeat (LTR) and cellular promoters via the CREB and NFkB pathways. In contrast to HTLV-1, HTLV-2 has been classified into four distinct genetic subtypes A...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/1742-4690-3-20
更新日期:2006-03-21 00:00:00
abstract::This editorial represents a plea to retrovirologists to attend the XVI International Conference on AIDS that will take place in Toronto, Canada between August 13-18, 2006. In short, it is vital that politicians and opinion leaders understand that basic scientists are no less committed to the worldwide battle against H...
journal_title:Retrovirology
pub_type: 社论
doi:10.1186/1742-4690-3-9
更新日期:2006-02-03 00:00:00
abstract:BACKGROUND:Extra-cellular roles of Tat might be the main cause of maintenance of HIV-1 infected CD4 T cells or reservoir cells. We developed a synthetic vaccine based on a Tat variant of 101 residues called Tat Oyi, which was identified in HIV infected patients in Africa who did not progress to AIDS. We compared, using...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/1742-4690-3-8
更新日期:2006-01-27 00:00:00
abstract:BACKGROUND:Efficient targeted gene transfer and cell type specific transgene expression are important for the safe and effective expression of transgenes in vivo. Enveloped viral vectors allow insertion of exogenous membrane proteins into their envelopes, which could potentially aid in the targeted transduction of spec...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/1742-4690-2-80
更新日期:2005-12-21 00:00:00
abstract:BACKGROUND:HIV-1 and all retroviruses are related to retroelements of simpler organisms such as the yeast Ty elements. Recent work has suggested that the yeast retroelement Ty1 replicates via an unexpected RNA lariat intermediate in cDNA synthesis. The putative genomic RNA lariat intermediate is formed by a 2'-5' phosp...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/1742-4690-2-63
更新日期:2005-10-18 00:00:00
abstract:BACKGROUND:The N-heptad repeat region of the HIV-1 Transmembrane Envelope protein is a trimerization domain that forms part of a "six helix bundle" crucial to Envelope-mediated membrane fusion. N-heptad repeat peptides have been used as extracellular reagents to inhibit virus fusion. RESULTS:When expressed intracellul...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/1742-4690-2-51
更新日期:2005-08-10 00:00:00
abstract:BACKGROUND:The positive transcription elongation factor b (P-TEFb) composed by CDK9/CyclinT1 subunits is a dedicated co-factor of HIV transcriptional transactivator Tat protein. Transcription driven by the long terminal repeat (LTR) of HIV involves formation of a quaternary complex between P-TEFb, Tat and the TAR eleme...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/1742-4690-2-42
更新日期:2005-07-02 00:00:00
abstract:BACKGROUND:The HIV-1 Rev regulatory protein binds as an oligomeric complex to viral RNA mediating nuclear export of incompletely spliced and non-spliced viral mRNAs encoding the viral structural proteins. However, the biological significance of the obligatory complex formation of Rev upon the viral RNA is unclear. RES...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/1742-4690-2-39
更新日期:2005-06-10 00:00:00
abstract:BACKGROUND:Reducing transmission of HIV-1 through breast milk is needed to help decrease the burden of pediatric HIV/AIDS in society. We have previously reported that alkyl sulfates (i.e., sodium dodecyl sulfate, SDS) are microbicidal against HIV-1 at low concentrations, are biodegradable, have little/no toxicity and a...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/1742-4690-2-28
更新日期:2005-04-29 00:00:00
abstract:BACKGROUND:Cellular infection with human immunodeficiency virus (HIV) both in vitro and in vivo requires a member of the chemokine receptor family to act as a co-receptor for viral entry. However, it is presently unclear to what extent the interaction of HIV proteins with chemokine receptors generates intracellular sig...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/1742-4690-2-23
更新日期:2005-04-04 00:00:00
abstract:BACKGROUND:All human immunodeficiency virus (HIV-1) uses a host tRNALys,3 as the primer for reverse transcription. The tRNALys,3 is bound to a region on the HIV-1 genome, the primer-binding site (PBS), that is complementary to the 18 terminal nucleotides of tRNALys,3. How HIV-1 selects the tRNA from the intracellular m...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/1742-4690-2-21
更新日期:2005-03-24 00:00:00
abstract:BACKGROUND:Retroviruses have a diploid genome and recombine at high frequency. Recombinant proviruses can be generated when two genetically different RNA genomes are packaged into the same retroviral particle. It was shown in several studies that recombinant proviruses could be generated in each round of HIV-1 replicat...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/1742-4690-2-3
更新日期:2005-01-18 00:00:00
abstract::A pol-fragment of simian immunodeficiency virus (SIV) that is highly related to SIVdrl-pol from drill monkeys (Mandrillus leucophaeus) was detected in two mandrills (Mandrillus sphinx) from Amsterdam Zoo. These captivity-born mandrills had never been in contact with drill monkeys, and were unlikely to be hybrids. Thei...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/1742-4690-1-36
更新日期:2004-11-01 00:00:00
abstract::The viral transactivator of HTLV-I, Tax, has long been shown to target the earliest steps of transcription by forming quaternary complexes with sequence specific transcription factors and histone-modifying enzymes in the LTR of HTLV-I. However, a new study suggests that Tax preferentially transactivates the 21-bp repe...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/1742-4690-1-19
更新日期:2004-07-30 00:00:00
abstract:BACKGROUND:The human T-cell leukemia virus type 1 (HTLV-1) Tax protein indirectly influences transcriptional activation, signal transduction, cell cycle control, and apoptosis. The function of Tax primarily relies on protein-protein interactions. We have previously shown that Tax upregulates the cell cycle checkpoint p...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/1742-4690-1-6
更新日期:2004-04-13 00:00:00